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Rhinology/Olfactory Research

Brad GoldsteinBrad Goldstein, MD, PhD

As a clinician-scientist, the goal of Dr. Goldstein's current research program is to study neurogenesis and tissue renewal in the olfactory mucosa, in an effort to begin to develop strategies to prevent or treat disorders that cause olfactory damage or loss. Disorders of the sense of smell are estimated to affect approximately >12% of Americans, with increased incidence in adults >65 years of age, and there are presently few treatment options available. In his clinical rhinology practice, he has particular interest in patients with smell and taste disorders. Dr. Goldstein is currently the principal investigator of a National Institutes of Health (NIH)-funded basic science laboratory, using mouse models, cell culture approaches, and human nasal tissue specimens. The lab utilizes multiple approaches to identify mechanisms regulating adult basal stem and progenitor cells in the olfactory epithelium, as well as olfactory tissue maintenance and renewal. The lab's overall goal is to understand the cellular and molecular mechanisms causing acquired human olfactory disorders, to facilitate the development of new treatments.

David JangDavid W. Jang, MD

The Rhinology and Endoscopic Skull Base Surgery research program maintains a database of all its patients, allowing for outcomes research in both inflammatory and neoplastic conditions as well as base of skull lesions. In addition, we utilize Duke University’s data repository (DEDUCE, or Duke Enterprise Data Unified Content Explorer) for retrospective studies. We also have research collaborations with Dennis O. Frank-Ito, PhD, within the Department of Head and Neck Surgery (computational fluid dynamics), and William Parker, PhD, in the Division of Surgical Sciences (biome enrichment with helminths) with the Duke Cystic Fibrosis Center and with the Duke Institute for Brain Sciences. We are collaborating with the Association of Migraine Disorders to develop a research protocol to evaluate whether patients with chronic sinus symptoms unresponsive to medical management might, in fact, have an atypical migraine condition.