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Airway Disease

Dennis Onyeka Frank-Ito, PhD

The focus of Dr. Frank-Ito's research is the application of computational methods to investigate physiology and pathophysiology of the nose, larynx, and ear. In particular, he is interested in the development of clinically applicable algorithms to efficiently identify the effects of pathological abnormality on functioning of the nose, larynx, and ear. Such algorithms will permit efficient detection and diagnosis of airway disease and help clinicians determine objective and systematic treatment options that will optimize patient outcomes. Briefly, my primary interests in the nose are: (1) to study the impact of sinonasal diseases on nasal airflow dynamics, olfactory function, and intranasal drug delivery; and (2) to investigate the relationship between nasal cavity morphology and nasal function. His research objectives in the larynx are to model laryngeal aerodynamic and aeroacoustic patterns in the healthy and pathological larynx and to model topical drug deposition in the larynx. In the ear, he is interested in quantifying the influence of temporal bone anatomy both on hearing loss and on vestibular function.

Xiaoyang HuaXiaoyang Hua, MD

Dr. Hua's research is focused on airway mucosal immunology, principally on how the nose immunologically impacts the lungs. As the first point of contact of the respiratory system with the environment, the nose can effectively filter, humidify, and warm inhaled air to minimize detrimental stimulation of the lower airway and lungs. Dr. Hua's team has also recently shown that activation of the nasal mucosal immune system can prime the airway and significantly enhance both innate and adaptive immunity in the lungs. Such nasal priming dramatically reduces the mortality and morbidity of lethal viral pneumonia. Their long-term goal is to further define the mechanisms by which the nose immunologically regulates the lungs, and to seek new strategies for nasal vaccine development.

Computational Modeling Research Lab

The Computational Modeling Research Laboratory combines computational fluid dynamics (CFD) modeling with three-dimensional (3D) reconstruction to investigate pathophysiology of the ear, nose and throat, as well as the effects of pathologic abnormality on normal functioning of the ear, nose, and throat.

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